JNK3 inhibitor-9

Product Description: JNK3 inhibitor-9 (Compound 24a) is a potent, selective and BBB-permeable JNK3 inhibitor with an IC50 value of 12 nM. JNK3 inhibitor-9 also potently inhibits GSK3α/β (IC50s: 14 and 35 nM, respectively) involved in Tau phosphorylation. JNK3 inhibitor-9 reduces c-Jun and APP phosphorylation. JNK3 inhibitor-9 protects neurons from Aβ1-42 toxicity[1].

Applications: Neuroscience-Neurodegeneration

Formula: C25H27N7O2

References: [1]Kim H, et al. Targeting JNK3 for Alzheimer's disease: Design and synthesis of novel inhibitors with aryl group diversity utilizing wide pocket. Eur J Med Chem. 2025 Jan 3;285:117209.

Molecular Weight: 457.53

Research Area: Neurological Disease

Target: Amyloid-β;GSK-3;JNK

• SKU: MEXHY-168859-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168859-0
• Package Unit: Get quote
• Quantity Unit: STK