JPS036, CAS 2669785-85-5

Product Description: JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Applications: Cancer-programmed cell death

Formula: C51H66FN7O7S

References: [1]Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659.

CAS Number: 2669785-85-5

Molecular Weight: 940.18

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: HDAC;PROTACs

• SKU: MEXHY-145819-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-145819-1
• Package Unit: 1 mg
• Quantity Unit: STK