Product Description: JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]Target: MAGL inhibitorJW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
Applications: Neuroscience-Neuromodulation
Formula: C21H20F6N2O3
References: [1]Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88.
CAS Number: 1416133-89-5
Molecular Weight: 462.39
Compound Purity: 99.90
Research Area: Neurological Disease
Solubility: DMSO : ≥ 100 mg/mL
Target: MAGL
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