Product Description: K284-6111 is an orally active inhibitor for protein chitinase 3-like 1 (CHI3L1). K284-6111 reduces the expression of inflammatory proteins such as iNOS, COX-2, GFAP, and Iba-1, inhibits β-secretase and NF-κB, and suppresses Aβ production. K284-6111 ameliorates the Aβ1–42-induced mice memory impairment, and can be used in research about Alzheimer’s Diseases[1].
Applications: Neuroscience-Neurodegeneration
Formula: C30H37N3O4S
References: [1]Choi JY, et al., K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression. J Neuroinflammation. 2018 Aug 11;15(1):224.
CAS Number: 702668-62-0
Molecular Weight: 535.70
Compound Purity: 99.94
Research Area: Neurological Disease
Solubility: DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Beta-secretase;NF-κB
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