Keap1-Nrf2-IN-25

Product Description: Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor (IC50 of 0.55 μM) with Keap1 binding affinity (Kd of 0.50 μM). Keap1-Nrf2-IN-25 activates Nrf2, reduces ROS and pro-inflammatory cytokines (IL-1β, IL-6). Keap1-Nrf2-IN-25 exerts protective effects against DSS (HY-116282)-induced colitis[1].

Applications: COVID-19-immunoregulation

Formula: C25H28N2O6S

References: [1]Zhao Z, et al. Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management. Eur J Med Chem. 2025 Feb 13;288:117384.

Molecular Weight: 484.56

Research Area: Inflammation/Immunology

Target: Interleukin Related;Keap1-Nrf2;Reactive Oxygen Species

• SKU: MEXHY-168922-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168922-0
• Package Unit: Get quote
• Quantity Unit: STK