Keap1-Nrf2-IN-9, CAS 2769963-24-6

Product Description: Keap1-Nrf2-IN-9 (compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows not cytotoxic activity in ARPE19 cells[1].

Applications: COVID-19-immunoregulation

Formula: C31H30N2O11S2

References: [1]Georgakopoulos N, et al. Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode. J Med Chem. 2022 May 26;65(10):7380-7398.

CAS Number: 2769963-24-6

Molecular Weight: 670.71

Compound Purity: 98.52

Research Area: Inflammation/Immunology; Neurological Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Keap1-Nrf2

• SKU: MEXHY-147517-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-147517-100
• Package Unit: 100 mg
• Quantity Unit: STK