Product Description: KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT[1][2].
Applications: Cancer-programmed cell death
Formula: C7H7FN6O2
References: [1]Huseman ED, et al. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. J Am Chem Soc. 2024 Jul 10;146(27):18241-18252./[2]HERZON Seth, et al. Preparation of imidazotetrazine compounds and methods for treating cancers that are MGMT deficient regardless of MMR status. WO2023049806. 2022 September 22.
CAS Number: 1161826-19-2
Molecular Weight: 226.17
Compound Purity: 99.82
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: DNA/RNA Synthesis
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