Product Description: KT-253 is a p53 stabilizer and a PROTAC degrader for MDM2 (DC50=0.4 nM). KT-253 inhibits the proliferation of cancer cell RS4;11 with an IC50 of 0.3 nM, arrests the cell cycle at G2/M phase, and induces apoptosis. KT-253 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein MDM2 ligand 4 (HY-170452); Black: linker (HY-W001478); Blue: ligand for E3 ligase cereblon (HY-163927))
Applications: Cancer-programmed cell death
Formula: C48H52Cl2FN7O6
References: [1]Chutake YK, et al., KT-253, A Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy Than MDM2 Small Molecule Inhibitors. Mol Cancer Ther. 2024 Dec 9.
CAS Number: 2713618-08-5
Molecular Weight: 912.87
Compound Purity: 98.53
Research Area: Cancer
Solubility: DMSO : 95 mg/mL (ultrasonic)
Target: Apoptosis;MDM-2/p53;PROTACs
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