KWR137

Product Description: KWR137 is a WRN degrader, with an IC50 of 8 nM. KWR137 exhibits good anti-proliferative activity against MSI-H cells, with a GI50 of 509 nM in SW48 cells and a GI50 of 824 μM in HCT116 cells. It also demonstrates anti-tumor growth effects in xenograft mouse models. KWR137 can be used for cancer research[1].

Formula: C33H31ClF3N9O4

References: [1]Moon B, et al. Discovery of novel WRN inhibitors for treating MSI-H colorectal cancers. Bioorg Med Chem Lett. 2025 Feb 15;120:130141.

Molecular Weight: 710.11

Research Area: Cancer

Target: DNA/RNA Synthesis

• SKU: MEXHY-168934-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168934-0
• Package Unit: Get quote
• Quantity Unit: STK