L1BC8, CAS 2417370-68-2

Product Description: L1BC8 (compound 13a) is a BRD4 PROTAC degrader with anticancer effects. L1BC8 is also a drug-linker conjugate for ADC that can be used for the synthesis of ADCs. The resulting BRD4-degrader antibody conjugates exhibit potent and antigen-dependent BRD4 degradation and antiproliferation activities in cell-based experiments. (Pink: BRD4 ligand (HY-129939); Blue: VHL ligand (HY-125845); Black: linker (HY-171663))[1].

Applications: Cancer-programmed cell death

Formula: C86H98F2N16O18S2

References: [1]Dragovich PS, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

CAS Number: 2417370-68-2

Molecular Weight: 1745.92

Compound Purity: 99.20

Research Area: Cancer

Target: Drug-Linker Conjugates for ADC;Epigenetic Reader Domain;PROTACs

• SKU: MEXHY-164995-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-164995-5
• Package Unit: 5 mg
• Quantity Unit: STK