LC3B ligand 2

Product Description: LC3B ligand 2 is a ligand for E3 ubiquitin ligase. LC3B ligand 2 can be connected to the ligand for protein by a linker to form PROTAC PCSK9 autophagic degrader 2 (HY-176043). PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

Formula: C15H8Br2INO2

References: [1]Wu H, et al. PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation. J Med Chem. 2025 Apr 24;68(8):8190-8207.

Molecular Weight: 520.94

Research Area: Cancer; Cardiovascular Disease

Target: Ligands for E3 Ligase

• SKU: MEXHY-176045-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-176045-0
• Package Unit: Get quote
• Quantity Unit: STK