LC3B recruiter 2, CAS 380636-64-6

LC3B recruiter 2, CAS 380636-64-6
SKU
MEXHY-168892-0
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MedChemExpress

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Product Description: LC3B recruiter 2 (34R) is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), which directly binds to LC3B. LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 (HY-10008) through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex (with inhibitory effects on both). Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity[1].

Formula: C10H9ClN2O2

References: [1]Zeng Y, et al. Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations. Eur J Med Chem. 2025 Apr 5;287:117293.

CAS Number: 380636-64-6

Molecular Weight: 224.64

Research Area: Cancer

Target: Atg8/LC3;ATTECs;Autophagy
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SKU MEXHY-168892-0
Manufacturer MedChemExpress
Manufacturer SKU HY-168892-0
Package Unit Get quote
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