LK-2, CAS 2649762-09-2

Product Description: LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable[1].

Applications: Neuroscience-Neuromodulation

Formula: C12H17N2O5P

References: [1]Lai K, et al., Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. Nature. 2024 Jul;631(8022):826-834.

CAS Number: 2649762-09-2

Molecular Weight: 300.25

Compound Purity: 98.11

Research Area: Neurological Disease

Solubility: H2O : 50 mg/mL (ultrasonic)

Target: Sodium Channel

• SKU: MEXHY-164284-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-164284-5
• Package Unit: 5 mg
• Quantity Unit: STK