Product Description: LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research[1].
Applications: COVID-19-immunoregulation
Formula: C20H17NO4
References: [1]Chen IC, et al. Investigating the therapeutic effects of novel compounds targeting inflammatory IL-1β and IL-6 signaling pathways in spinocerebellar ataxia type 3. Eur J Pharmacol. 2024 Mar 15;967:176370.
CAS Number: 1022282-98-9
Molecular Weight: 335.35
Compound Purity: 98.27
Research Area: Inflammation/Immunology; Neurological Disease
Solubility: DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Caspase;Interleukin Related;Lactate Dehydrogenase;Reactive Oxygen Species
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