LO-4-25

Product Description: LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its truncated variant AR-V7. LO-4-25 covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, promoting the ubiquitination of AR and AR-V7, which subsequently are recognized and degraded by the proteasome, reducing the protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research of androgen-independent prostate cancers[1].

Applications: Cancer-programmed cell death

Formula: C32H37ClN6O6

References: [1]Lauren M Orr, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. bioRxiv [Preprint]. April 25, 2025.

Molecular Weight: 637.13

Research Area: Cancer

Target: Androgen Receptor

• SKU: MEXHY-176067-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-176067-0
• Package Unit: Get quote
• Quantity Unit: STK