Product Description: LY3130481 is an orally available AMPA receptor antagonist, selectively inhibiting the IC50 value of AMPA/TARP γ-8 at 65 nM. LY3130481 has anticonvulsant, antiepileptic, and pain-relieving effects[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C19H18N4O3S
References: [1]Gardinier KM,et al. Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. J Med Chem. 2016 May 26;59(10):4753-68./[2]Kelly L Knopp, et al. Modulation of TARP γ 8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain. J Pharmacol Exp Ther. 2019 Jun;369(3):345-363.
CAS Number: 1610802-47-5
Molecular Weight: 382.44
Compound Purity: 99.84
Research Area: Neurological Disease
Solubility: DMSO : 250 mg/mL (ultrasonic)
Target: iGluR
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