LYG-409, CAS 3053857-55-6

Product Description: LYG-409 is an orally active degrader of GSPT1. LYG-409 shows excellent anti-acute myeloid leukemia and prostate cancer in vivo with TGI of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells mediated by the degradation of GSPT1 with an IC50 of 9.50 nM, with a DC50 of 7.87 nM in vitro[1].

Applications: Cancer-programmed cell death

Formula: C25H20F3N3O6

References: [1]Zhang Y, et al. Design and Discovery of Preclinical Candidate LYG-409 as a Highly Potent and Selective GSPT1 Molecular Glue Degraders. J Med Chem. 2025 Feb 13;68(3):2608-2638.

CAS Number: 3053857-55-6

Molecular Weight: 515.44

Compound Purity: 98.11

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Molecular Glues

• SKU: MEXHY-170952-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170952-50
• Package Unit: 50 mg
• Quantity Unit: STK