M4K2163 (dihydrochloride), CAS 2863635-04-3

Product Description: M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG)[1][2].

Applications: Cancer-Kinase/protease

Formula: C24H28Cl2FN3O2

References: [1]Smil D, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 Sep 10;63(17):10061-10085./[2]Rooney L, et al. Recent Advances in ALK2 Inhibitors. ACS Omega. 2021 Aug 6;6(32):20729-20734.

CAS Number: 2863635-04-3

Molecular Weight: 480.40

Compound Purity: 98.30

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: TGF-β Receptor

• SKU: MEXHY-155939-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155939-25
• Package Unit: 25 mg
• Quantity Unit: STK