Product Description: MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05 nM, 14 nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic[1].
Applications: COVID-19-immunoregulation
Formula: C20H16ClNO3
References: [1]Dhiman P, et al. Discovery of Conformationally Constrained Dihydro Benzo-Indole Derivatives as Metallo-β-Lactamase Inhibitors to Tackle Multidrug-Resistant Bacterial Infections. J Med Chem. 2025 Apr 10;68(7):7062-7081.
CAS Number: 2876921-34-3
Molecular Weight: 353.80
Research Area: Infection
Target: Bacterial;Beta-lactamase
English
Deutsch
