MEL23, CAS 642072-49-9

Product Description: MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription[1].

Applications: Cancer-programmed cell death

Formula: C19H22N4O3

References: [1]Divya Venkatesh, et al. MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling. Genes Dev. 2020 Apr 1;34(7-8):526-543./[2]Herman AG, et al. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011 Sep;1(4):312-25.

CAS Number: 642072-49-9

Molecular Weight: 354.40

Research Area: Cancer

Target: Ligands for E3 Ligase

• SKU: MEXHY-148106-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-148106-0
• Package Unit: Get quote
• Quantity Unit: STK