Menin–KMT2A-IN-1

Product Description: Menin–KMT2A-IN-1 (Compound 20) is the inhibitor for menin–KMT2A that binds to menin with an IC50 of 8 nM, and inhibits the interaction between menin and lysine methyltransferase 2A (KMT2A). Menin–KMT2A-IN-1 inhibits hERG with an IC50 of 65 μM. Menin–KMT2A-IN-1 inhibits cell MV4-11 with an IC50 of 74 nM. Menin–KMT2A-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mouse with an orally bioavailability of 74%[1].

Applications: Cancer-programmed cell death

Formula: C28H35FN6O3

References: [1]Chapsal BD, et al., Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity. ACS Med Chem Lett. 2024 Dec 31;16(2):224-233.

Molecular Weight: 522.61

Research Area: Cancer

Target: Epigenetic Reader Domain;Potassium Channel

• SKU: MEXHY-170832-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170832-0
• Package Unit: Get quote
• Quantity Unit: STK