MGD-28, CAS 2991818-13-2

Product Description: MGD-28 is a potent, orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM). MGD-28 has antiproliferative activity and can be used in multiple myeloma research[1].

Formula: C33H34FN7O3

References: [1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17(1): 77.

CAS Number: 2991818-13-2

Molecular Weight: 595.67

Compound Purity: 99.73

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Casein Kinase;IKZF Family

• SKU: MEXHY-168615-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168615-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK