Product Description: MK-0873 is a selective phosphodiesterase-4 (PDE4) inhibitor. MK-0873 increases intracellular levels of cyclic adenosine phosphate (cAMP) by inhibiting the activity of the PDE4 enzyme and subsequently activates protein kinase A (PKA). Activated PKA inhibits the activity of inflammatory cells and leads to direct relaxation of airway smooth muscle. MK-0873 can be used in studies of chronic obstructive pulmonary disease (COPD)[1].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C25H18N4O3
References: [1]Boot J D, et al. MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers[J]. Pulmonary Pharmacology & Therapeutics, 2008, 21(3): 573-577.
CAS Number: 500355-52-2
Molecular Weight: 422.44
Research Area: Metabolic Disease; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Phosphodiesterase (PDE)
English
Deutsch
