Product Description: Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice[1][2].
Applications: COVID-19-immunoregulation
Formula: C200H241N69O107P20S20Na20
References: [1]Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372(12):1104-13./[2]Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24(6):1213-1224.
CAS Number: 1443994-98-6
Molecular Weight: 7044.00
Compound Purity: 99.61
Research Area: Inflammation/Immunology
Solubility: H2O : ≥ 100 mg/mL
Target: TGF-beta/Smad
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