MRTX-0902, CAS 2654743-22-1

Formulation: A solid

Formal Name: 2-methyl-3-[(1R)-1-[[4-methyl-7-(4-morpholinyl)pyrido[3,4-d]pyridazin-1-yl]amino]ethyl]-benzonitrile

Purity: ≥98%

Formula Markup: C22H24N6O

Formula Weight: 388,5

Shelf life (days): 1460

CAS Number: 2654743-22-1

Notes: MRTX-0902 is an inhibitor of the protein-protein interaction between son of sevenless homolog 1 (SOS1) and K-Ras containing a glycine-to-cysteine mutation at position 12 (K-RasG12C; Ki = 1.9 nM).{68617} It is selective for the SOS1-K-RasG12C protein-protein interaction over the SOS1 and wild-type K-Ras protein-protein interaction (IC50 = >10,000 nM). MRTX-0902 decreases phosphorylated ERK levels in MKN1 gastric adenosquamous carcinoma cells (IC50 = 29 nM). In vivo, MRTX-0902 (25 or 50 mg/kg twice per day), in combination with the covalent inhibitor of K-RasG12C MTX-849 (Item No. 31440), reduces tumor volume and phosphorylated ERK levels in a PaCa-2 pancreatic cancer mouse xenograft model.

• SKU: CAY38578-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38578-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK