MS479

MS479
SKU
MEXHY-176035-0
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Manufacturer
MedChemExpress

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Product Description: MS479 is a BRD4 PROTAC degrader. MS479 binds BRD4-BD2 and GLP with high affinities (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). MS479 can reduce the protein level of BRD4 short isoform. MS479 recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein. MS479 can be used to inhibit the proliferation of colorectal cancer cells. (Pink: BRD4 ligand (HY-78695); Blue: GLP ligand (HY-176036); Black: linker (HY-176037); GLP ligand+linker: HY-176038)[1].

Applications: Cancer-programmed cell death

Formula: C59H82ClN11O5S

References: [1]Deng Z, et al., Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation. J Med Chem. 2025 Apr 24;68(8):8634-8647.

Molecular Weight: 1092.87

Research Area: Cancer

Target: Epigenetic Reader Domain;PROTACs
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SKU MEXHY-176035-0
Manufacturer MedChemExpress
Manufacturer SKU HY-176035-0
Package Unit Get quote
Quantity Unit STK
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