Mtb-IN-10

Product Description: Mtb-IN-10 (Compound P15) is a Rv1625c/Cya activator that regulates cAMP metabolism to influence the growth of Mycobacterium tuberculosis (Mtb). Mtb-IN-10 exhibits an EC50 of 1.96 µM in an Mtb-infected macrophage model and demonstrates 58.0% oral bioavailability in mice at a 20 mg/kg dose. It may regulate intracellular signaling and disrupt cholesterol metabolism in Mtb, thereby inhibiting bacterial proliferation. Mtb-IN-10 holds potential for tuberculosis (TB) research, particularly for combating multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) Mtb strains[1].

Applications: COVID-19-immunoregulation

Formula: C12H14N2O4S2

References: [1]Martinez G, et al. Novel isoxazole thiophene-containing compounds active against Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2025 Apr 15;119:130108.

Molecular Weight: 314.38

Research Area: Infection

Target: Bacterial

• SKU: MEXHY-170970-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170970-0
• Package Unit: Get quote
• Quantity Unit: STK