MU147, CAS 2379405-61-3

Product Description: MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer activity, which is lethal to Ehrlich ascites tumor cells both in vitro and in vivo. MU147 also eliminates the double-strand break repair mechanism dependent on the MRE11 nuclease activity without impairing the activation of ATM. MU147 also impairs the degradation of nascent strands of stalled replication FOX and selectively affects brca2-deficient cells[1].

Applications: Cancer-programmed cell death

Formula: C19H13N3O3S

References: [1]Nikulenkov F, et al. Discovery of new inhibitors of nuclease MRE11. Eur J Med Chem. 2025 Mar 5;285:117226.

CAS Number: 2379405-61-3

Molecular Weight: 363.39

Compound Purity: 99.35

Research Area: Cancer

Solubility: DMSO : 116.67 mg/mL (ultrasonic)

Target: Endonuclease

• SKU: MEXHY-170844-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170844-10
• Package Unit: 10 mg
• Quantity Unit: STK