NA-184, CAS 2688119-39-1

Product Description: NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI)[1].

Applications: Neuroscience-Neuromodulation

Formula: C27H35ClN4O5

References: [1]Baudry M, et al. Identification and neuroprotective properties of NA-184, a calpain-2 inhibitor. Pharmacol Res Perspect. 2024 Apr;12(2):e1181.

CAS Number: 2688119-39-1

Molecular Weight: 531.04

Compound Purity: 99.66

Research Area: Neurological Disease

Solubility: DMSO : ≥ 100 mg/mL

Target: Proteasome

• SKU: MEXHY-155482-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155482-1
• Package Unit: 1 mg
• Quantity Unit: STK