Product Description: NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Applications: Metabolism-sugar/lipid metabolism
Formula: C27H31NOS2
Citations: Adv Sci (Weinh). 2023 Sep;10(27):e2206878./Antioxidants (Basel). 2024 Jun 13;13(6):722./Arch Pharm (Weinheim). 2025 Feb;358(2):e2400807./Cancer Res. 2022 Sep 2;82(17):3032-3044./Cell Chem Biol. 2021 Feb 16;S2451-9456(21)00051-9./Cell Metab. 2020 Apr 7;31(4):862-877.e14./Genome Biol. 2016 Jun 29;17(1):140. /J Steroid Biochem Mol Biol. 2015 Aug;152:34-44./Sci China Life Sci. 2021 May 27;1-21./Cell Death Dis. 2021 May 13;12(5):482./Cell Rep. 2020 Aug 4;32(5):107944./Nat Chem Biol. 2016 Jul;12(7):497-503. /University of Toronto. Department of Medical Biophysics
References: [1]Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45./[2]Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305./[3]Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.
CAS Number: 131060-14-5
Molecular Weight: 449.67
Compound Purity: 98.69
Research Area: Metabolic Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: COX
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