NF-κB/HIF-1α-IN-1

Product Description: NF-κB/HIF-1α-IN-1 (compound 9c) is a potent blocker of the NF-κB activation pathway and demonstrates selective anti-fibrotic activity. NF-κB/HIF-1α-IN-1 shows no significant cytotoxicity in NCI tumor cell lines. In rat models. NF-κB/HIF-1α-IN-1 has been shown to effectively ameliorate liver fibrosis by inhibiting the expression levels of NF-κB and HIF-1α, while simultaneously inducing the activation of Nrf2[1].

Formula: C24H27N7O4

References: [1]Abdalla R Mohamed, et al. Unveiling the potential of xanthines, discovery of potential 7-benzyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione derivatives with antifibrotic activity for liver injury. Bioorg Chem. 2025 Jun 15:160:108441.

Molecular Weight: 477.52

Research Area: Cancer

Target: HIF/HIF Prolyl-Hydroxylase;Keap1-Nrf2;NF-κB

• SKU: MEXHY-173488-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173488-0
• Package Unit: Get quote
• Quantity Unit: STK