NF-κB/MAPK-IN-2

Product Description: NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis[1].

Formula: C49H66N2O9

References: [1]Xie W, et al. Design and Synthesis of Hederagenin Derivatives for the Treatment of Sepsis by Targeting TAK1 and Regulating the TAK1-NF-κB/MAPK Signaling. J Med Chem. 2025 Jan 16.

Molecular Weight: 827.06

Research Area: Cancer

Target: NF-κB;p38 MAPK

• SKU: MEXHY-168482-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168482-0
• Package Unit: Get quote
• Quantity Unit: STK