NLRP3-IN-70, CAS 1997362-01-2

Product Description: NLRP3-IN-70 (Compound 5m) is an NLRP3 inflammasome inhibitor with low oral bioavailability. NLRP3-IN-70 can directly bind to the NACHT domain of the NLRP3 protein and block the interaction of NLRP3 and ASC, thus inhibiting ASC oligomerization and NLRP3 inflammasome assembly. NLRP3-IN-70 can be used in the research of sepsis and nonalcoholic steatohepatitis[1].

Formula: C23H23NO5

References: [1]Zhu K, et al. Peripheral Evolution of Tanshinone IIA and Cryptotanshinone for Discovery of a Potent and Specific NLRP3 Inflammasome Inhibitor. J Med Chem. 2025 Feb 13;68(3):3460-3479.

CAS Number: 1997362-01-2

Molecular Weight: 393.43

Research Area: Inflammation/Immunology

Target: NOD-like Receptor (NLR)

• SKU: MEXHY-172134-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172134-0
• Package Unit: Get quote
• Quantity Unit: STK