NLRP3-IN-75

Product Description: NLRP3-IN-75 is an orally active NLRP3 inhibitor. NLRP3-IN-75 suppresses IL-1β secretion (IC50 = 23 nM). NLRP3-IN-75 selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 exhibits superior efficacy in acute peritonitis, diabetic kidney disease and IBD models[1].

Applications: COVID-19-immunoregulation

Formula: C20H30N4O3S

References: [1]1.Liu Y, et al., Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment of Multiple Inflammatory Diseases. J Med Chem.

Molecular Weight: 406.54

Research Area: Inflammation/Immunology

Target: Interleukin Related;NF-κB;NOD-like Receptor (NLR)

• SKU: MEXHY-170233-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170233-0
• Package Unit: Get quote
• Quantity Unit: STK