NLRP3-IN-77, CAS 2924547-57-7

Product Description: NLRP3-IN-77 (Compound 7n) is a potent NLRP3 inflammasome inhibitor. NLRP3-IN-77 inhibits the viability of THP-1 cells with an IC50 value of 5.36 nM. NLRP3-IN-77 can effectively reduce the secretion of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3-IN-77 is promising for research of diseases related to the abnormal activation of the NLRP3 inflammasome, such as cancer and inflammatory diseases[1].

Formula: C28H29N3O3S

References: [1]Albanese V, et al. Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer. J Med Chem. 2023 Apr 13;66(7):5223-5241.

CAS Number: 2924547-57-7

Molecular Weight: 487.61

Research Area: Cancer; Inflammation/Immunology

Target: Interleukin Related;NOD-like Receptor (NLR)

• SKU: MEXHY-171589-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-171589-0
• Package Unit: Get quote
• Quantity Unit: STK