Product Description: NNC-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1) with IC50 values of 0.04, 0.38, 171, 1700, 349, 622 μM for human GAT-1, rat GAT-1, rGAT-2, hGAT-3, rGAT-3, hBGT-3, respectively. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity[1][2][3][4][5].
Applications: Neuroscience-Neuromodulation
Formula: C21H23ClN2O3
References: [1]Borden LA, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24. /[2]O'Connell AW, et al. Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric acid reuptake inhibitor. Eur J Pharmacol. 2001 Jul 13;424(1):37-44./[3]Li Y,et al. Analgesic effect of intrathecally γ-aminobutyric acid transporter-1 inhibitor NO-711 administrating on neuropathic pain in rats. Neurosci Lett. 2011 Apr 20;494(1):6-9. /[4]Suzdak PD, et al. NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur J Pharmacol. 1992 Dec 2;224(2-3):189-98./[5]Fattorini G, et al. Microglial expression of GAT-1 in the cerebral cortex. Glia. 2020 Mar;68(3):646-655.
CAS Number: 145645-62-1
Molecular Weight: 386.87
Compound Purity: 99.76
Research Area: Neurological Disease
Solubility: H2O : 4 mg/mL (ultrasonic;warming)/DMSO : 100 mg/mL (ultrasonic)
Target: GABA Receptor
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