Nrf2/HO-1 activator 3

Product Description: Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H2O2- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy[1].

Formula: C27H26N2O6

References: [1]Zheng Z, et al. Design and synthesis of novel antioxidants derived from chalcones and their protective effects on cardiomyocytes by activating Nrf2/HO-1 pathway[J]. Bioorganic & Medicinal Chemistry Letters, 2025, 118: 130086.

Molecular Weight: 474.51

Research Area: Cardiovascular Disease

Target: Heme Oxygenase (HO);Keap1-Nrf2;Reactive Oxygen Species

• SKU: MEXHY-170867-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170867-0
• Package Unit: Get quote
• Quantity Unit: STK