Numidargistat, CAS 2095732-06-0

Product Description: Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].

Applications: Cancer-programmed cell death

Formula: C11H22BN3O5

Citations: Biomed Pharmacother. 2022 Jun 24;153:113321./Research Square Preprint. 2022 Mar./The University of Chicago. 2023 Dec./bioRxiv. 2023 Sep 10./Cancer Cell . 2025 Feb 10;43(2):269-291.e19. /Cancer Lett. 2023 May 5;216208./Cell Commun Signal. 2023 Sep 18;21(1):236./J Physiol. 2020 Nov;598(21):4907-4925./Patent. US20240307497A1.

References: [1]Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101.

CAS Number: 2095732-06-0

Molecular Weight: 287.12

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Arginase

• SKU: MEXHY-101979-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101979-25
• Package Unit: 25 mg
• Quantity Unit: STK