Nur77 modulator 4

Nur77 modulator 4
SKU
MEXHY-170849-0
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MedChemExpress

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Product Description: Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. Nur77 modulator 4 significantly induces Nur77 expression and apoptosis, showing excellent growth inhibition in HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, thereby inducing cell apoptosis. Nur77 modulator 4 can be used in cancer research applications [1].

Formula: C26H28ClN5O2

References: [1]Hu H, et al. Design, synthesis, and biological evaluation of N1-(2-(adamantan-1-yl)-1H-indol-5-yl)-N2-(substituent)-1,2-dicarboxamides as anticancer agents targeting Nur77-mediated endoplasmic reticulum stress. Bioorg Chem. 2025 Feb;155:108113.

Molecular Weight: 477.99

Research Area: Cancer

Target: Apoptosis;IRE1;Nuclear Hormone Receptor 4A/NR4A;PERK
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SKU MEXHY-170849-0
Manufacturer MedChemExpress
Manufacturer SKU HY-170849-0
Package Unit Get quote
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