Product Description: Olprinone (Loprinone) Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone Hydrochloride is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].
Applications: COVID-19-immunoregulation
Formula: C14H11ClN4O
References: [1]Sugioka M, et al. Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes. Naunyn Schmiedebergs Arch Pharmacol. 1994;350(3):284-293./[2]Di Paola R, et al. Olprinone, a PDE3 inhibitor, modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats. Eur J Pharmacol. 2011;650(2-3):612-620.
CAS Number: 119615-63-3
Molecular Weight: 286.72
Compound Purity: 99.85
Research Area: Cardiovascular Disease
Solubility: H2O : ≥ 7.69 mg/mL
Target: Phosphodiesterase (PDE)
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