Product Description: Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].
Applications: COVID-19-immunoregulation
Formula: C29H40N4O7.HCl
Citations: J Antimicrob Chemother. 2021 Feb 11;76(3):653-658./J Antimicrob Chemother. 2021 May 6;dkab141./Virulence. 2022 Dec;13(1):77-88./Animal Feed Science and Technology. 2014 Dec;198:323-332./Ann Lab Med. 2021 May 1;41(3):293-301./Antibiotics (Basel). 2022, 11(10), 1298./Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00470-19./Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02097-19./Antimicrob Agents Chemother. 2023 Jan 23;e0145922./Antimicrob Agents Chemother. 2024 Oct 29:e0105124./Clin Exp Pharmacol Physiol. 2023 Apr 22./Comput Intell Neurosci. 2022 Apr 25;2022:7636983./Cureus. 2024 Dec 1;16(12):e74917./Diagn Micr Infec Dis. 2020 Nov;98(3):115129./J Antibiot (Tokyo). 2022 Jun 27./J Clin Microbiol. 2020 Jan 28;58(2):e01603-19./Microbiol Spectr. 2022 Dec 8;e0323822./Microbiol Spectr. 2023 May 4;e0071823./Nat Microbiol. 2023 Mar;8(3):410-423./Nat Struct Mol Biol. 2023 Aug 7./Open Forum Infect Dis. 2024 Oct 11;11(11):ofae611./PLoS Biol. 2022 Sep 28;20(9):e3001808./Research Square Preprint. 2020 Jun./Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0063824.
References: [1]Macone AB, et, al. In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother. 2014;58(2):1127-35./[2]Durães F, et, al. Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines. Pharmaceuticals (Basel). 2019 Apr 21;12(2):63./[3]Zhanel GG, et, al. Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs. 2020 Feb;80(3):285-313./[4]Markham A, et, al. Omadacycline: First Global Approval. Drugs. 2018 Dec;78(18):1931-1937.
CAS Number: 1196800-39-1
Molecular Weight: 593.11
Compound Purity: 99.87
Research Area: Infection
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 200 mg/mL (ultrasonic)
Target: Antibiotic;Bacterial
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