P-gb-IN-1, CAS 2632874-49-6

Product Description: P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells[1].

Applications: Cancer-programmed cell death

Formula: C30H28N2O6

References: [1]Zhikun Yang, et al. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell. Eur J Med Chem. 2023 Sep 5;257:115462.

CAS Number: 2632874-49-6

Molecular Weight: 512.55

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: P-glycoprotein

• SKU: MEXHY-149360-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-149360-1
• Package Unit: 1 mg
• Quantity Unit: STK