P-gp inhibitor 15, CAS 2303508-09-8

Product Description: P-gp inhibitor 15 (compound 7a) is a nonsubstrate inhibitor of P-glycoprotein (Pgp). P-gp inhibitor 15 inhibits Pgp-ATPase activity，and interfers Pgp-mediated Rhodamine123 efflux. P-gp inhibitor 15 also enhances the inhibitory efficacy of Paclitaxel (HY-B0015)，inhibits tumor progress in nude mice KBV xenograft tumors model[1].

Applications: Cancer-programmed cell death

Formula: C35H60N2O4

References: [1]Yang G, et al. Discovery of Pyxinol Amide Derivatives Bearing Amino Acid Residues as Nonsubstrate Allosteric Inhibitors of P-Glycoprotein-Mediated Multidrug Resistance. J Med Chem. 2023 Jul 13;66(13):8628-8642.

CAS Number: 2303508-09-8

Molecular Weight: 572.86

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: P-glycoprotein

• SKU: MEXHY-155032-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155032-1
• Package Unit: 1 mg
• Quantity Unit: STK