Pamapimod, CAS 449811-01-2

Product Description: Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment[1].

Applications: Cancer-Kinase/protease

Formula: C19H20F2N4O4

References: [1]Hill, R. J. et al. Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity. The Journal of pharmacology and experimental therapeutics 327, 610-619, doi:10.1124/jpet.108.139006 (2008).

CAS Number: 449811-01-2

Molecular Weight: 406.38

Compound Purity: 99.92

Research Area: Inflammation/Immunology

Solubility: DMSO : ≥ 34 mg/mL

Target: Autophagy;p38 MAPK

• SKU: MEXHY-10405-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10405-100
• Package Unit: 100 mg
• Quantity Unit: STK