Paquinimod, CAS 248282-01-1

Product Description: Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C21H22N2O3

References: [1]Schelbergen RF, et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis. 2015 Dec;74(12):2254-8./[2]Tahvili S, et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse. PLoS One. 2018 May 9;13(5):e0196598./[3]Qirui Guo, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021 Feb 10;29(2):222-235.e4.

CAS Number: 248282-01-1

Molecular Weight: 350.41

Compound Purity: 99.90

Research Area: Metabolic Disease; Inflammation/Immunology

Solubility: DMSO : 62.5 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: SARS-CoV

• SKU: MEXHY-100442-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100442-25
• Package Unit: 25 mg
• Quantity Unit: STK