PARP1/2/TNKS1/2-IN-1, CAS 2243453-32-7

Product Description: PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis[1].

Applications: Cancer-programmed cell death

Formula: C35H31FN6O5

References: [1]Xu Y, et al. Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy. Eur J Med Chem. 2022 Jul 5;237:114417.

CAS Number: 2243453-32-7

Molecular Weight: 634.66

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;PARP

• SKU: MEXHY-146336-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-146336-10
• Package Unit: 10 mg
• Quantity Unit: STK