PD-1/PD-L1 Inhibitor N11

Formulation: A solid

Formal Name: 2-methyl-2-(((4-(4-phenylindolin-1-yl)pyrido[3,2-d]pyrimidin-7-yl)methyl)amino)propan-1-ol

Purity: ≥95%

Formula Markup: C26H27N5O

Formula Weight: 425,5

Shelf life (days): 730

Notes: PD-1/PD-L1 inhibitor N11 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1; IC50 = 6.3 nM).{67611} It increases T cell proliferation in a PD-L1-overexpressing CT26 colon cancer cell and T cell co-culture when used at a concentration of 20 nM. PD-1/PD-L1 inhibitor N11 (20 and 80 nM) promotes T cell infiltration into an in vitro PD-L1-overexpressing murine Lewis lung carcinoma tumor matrix. In vivo, PD-1/PD-L1 inhibitor N11 (20 mg/kg) reduces tumor growth and promotes CD8+ and CD4+ T cell tumor infiltration in a PD-L1-overexpressing murine Lewis lung carcinoma model.

• SKU: CAY39663-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39663-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK