PDE10A-IN-5

Product Description: PDE10A-IN-5 (Compound A30) is an inhibitor of phosphodiesterase 10A (PDE10A) with oral activity, and its IC50 value is 3.5 nM. PDE10A-IN-5 exerts the activity of inhibiting pulmonary vascular remodeling by inhibiting PDE10A and activating the cyclic adenosine monophosphate (cAMP)-associated signaling pathway, and can be used for research in the field of pulmonary arterial hypertension[1].

Applications: Neuroscience-Neuromodulation

Formula: C29H34N6O3

References: [1]Huang H, et al. Discovery of novel azetidine-based imidazopyridines as selective and orally bioavailable inhibitors of phosphodiesterase 10A for the treatment of pulmonary arterial hypertension. Eur J Med Chem. 2025 Jun 5;290:117537.

Molecular Weight: 514.62

Research Area: Cardiovascular Disease

Target: Phosphodiesterase (PDE)

• SKU: MEXHY-173360-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173360-0
• Package Unit: Get quote
• Quantity Unit: STK