PDE4-IN-26

Product Description: PDE4-IN-26 (Compound A5) is an orally active and highly selective PDE4 inhibitor. PDE4-IN-26 has anti-inflammatory activity and can inhibit the phosphorylation of p38 MAPK. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 can improve pulmonary inflammation, injury and fibrosis, promote sputum secretion and relieve cough in mice. PDE4-IN-26 can be used for the research of lung injury-related diseases[1].

Formula: C22H18F2N4O3S

References: [1]Li M, et al. Design, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury. J Med Chem. 2025 Feb 13;68(3):3837-3857.

Molecular Weight: 456.47

Research Area: Inflammation/Immunology

Target: p38 MAPK;Phosphodiesterase (PDE)

• SKU: MEXHY-172135-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172135-0
• Package Unit: Get quote
• Quantity Unit: STK