Product Description: PF-07038124 hydrochloride is a PDE4 inhibitor with an IC50 of 0.5 nM for PDE4B2. PF-07038124 hydrochloride shows inhibitory activities against IL-13, IL4, and IFNγ (IC50=125, 4.1, 1.06 nM, respectively). PF-07038124 hydrochloride can be used for research of atopic dermatitis and plaque psoriasis[1][2].
Formula: C18H23BClNO4
References: [1]Boron containing pde4 inhibitors.WO2020070651A1./[2]Eichenfield LF, et al. Efficacy and Safety of PF-07038124 in Patients With Atopic Dermatitis and Plaque Psoriasis: A Randomized Clinical Trial. JAMA Dermatol. 2024 Feb 1;160(2):156-163.
CAS Number: 2415317-57-4
Molecular Weight: 363.64
Research Area: Inflammation/Immunology
Target: Phosphodiesterase (PDE)